Chiral phosphoric acid-catalyzed enantioselective aza-Friedel-Crafts alkylation of indoles with γ-hydroxy-γ-lactams

• المؤلفون الرئيسيون: Thibaut Courant, Sirirat Kumarn, Long He, Pascal Retailleau, Géraldine Masson
• مؤلفون آخرون: Institut de Chimie des Substances Naturelles
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Chemical Engineering; Chemistry
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/31483

An enantioselective aza-Friedel-Crafts reaction of indoles with γ-hydroxy-γ-lactams using a chiral phosphoric acid catalyst is reported. The approach described herein provides an efficient access to 5-indolylpyrrolidinones in good to quantitative yields and excellent enantioselectivities (up to >...