An Intradermal Inoculation Model of Scrub Typhus in Swiss CD-1 Mice Demonstrates More Rapid Dissemination of Virulent Strains of Orientia tsutsugamushi

• Main Authors: Piyanate Sunyakumthorn, Daniel H. Paris, Teik Chye Chan, Margaret Jones, Alison Luce-Fedrow, Suchismita Chattopadhyay, Ju Jiang, Tippawan Anantatat, Gareth D.H. Turner, Nicholas P.J. Day, Allen L. Richards
• Other Authors: Naval Medical Research Center
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31086
• Institution: Mahidol University

Scrub typhus is an important endemic disease of the Asia-Pacific region caused by Orientia tsutsugamushi. To develop an effective vaccine to prevent scrub typhus infection, a better understanding of the initial host-pathogen interaction is needed. The objective of this study was to investigate early...