Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G<inf>2</inf>cell cycle arrest, and caspase-independent death in a Saccharomyces cerevisiae model

• Main Authors: Oranart Matangkasombut, Roongtiwa Wattanawaraporn, Keiko Tsuruda, Masaru Ohara, Motoyuki Sugai, Skorn Mongkolsuk
• 其他作者: Chulalongkorn University
• 格式: Article
• 出版: 2018
• 主題: Immunology and Microbiology; Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/29276
• 機構: Mahidol University

Cytolethal distending toxin (CDT) is a bacterial toxin that induces G2/M cell cycle arrest, cell distension, and/or apoptosis in mammalian cells. It is produced by several Gram-negative species and may contribute to their pathogenicity. The catalytic subunit CdtB has homology with DNase I and may ac...