Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated β-amino acid

• Main Authors: Nopporn Thasana, Benjaphorn Prapagdee, Nuchanart Rangkadilok, Ratiboot Sallabhan, Seaim Lwin Aye, Somsak Ruchirawat, Suvit Loprasert
• Other Authors: Chulabhorn Graduate Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28676
• Institution: Mahidol University

Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common α-amino acids, l-Asn-1, d-Tyr-2, d-Asn-3, l-Gln-4, l-Pro-5, d-Asn-6, l-Ser-7 and the unique β-amino acid-8 present in the iturin family. 1D and 2D...