Genetic changes during laboratory propagation: Copy number At the reticulocyte-binding protein 1 locus of Plasmodium falciparum

• Main Authors: Shalini Nair, Standwell Nkhoma, François Nosten, Mayfong Mayxay, Neil French, Jim Whitworth, Tim Anderson
• Other Authors: Texas Biomedical Research Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28669
• Institution: Mahidol University

Comparative genomic hybridization studies have revealed elevated copy number (CN) at the reticulocyte-binding protein 1 gene (PfRh1) in fast growing lab-adapted parasites, while genetic manipulation demonstrates a causal link between cell invasion and PfRh1 CN. We therefore examined PfRh1 copy numbe...