Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

• المؤلفون الرئيسيون: Khanit Sa-ngiamsuntorn, Adisak Wongkajornsilp, Kanda Kasetsinsombat, Sunisa Duangsa-ard, Lalana Nuntakarn, Suparerk Borwornpinyo, Pravit Akarasereenont, Somchai Limsrichamrern, Suradej Hongeng
• مؤلفون آخرون: Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Pharmacology
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Open Access article; hepatocyte-like cell; immortalization; CYP450; MSC
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/2638

Background: The strenuous procurement of cultured human hepatocytes and their short lives have constrained the cell culture model of cytochrome P450 (CYP450) induction, xenobiotic biotransformation, and hepatotoxicity. The development of continuous non-tumorous cell line steadily containing hepato...