Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei

• Main Authors: Narisara Chantratita, Vanaporn Wuthiekanun, Khaemaporn Boonbumrung, Rachaneeporn Tiyawisutsri, Mongkol Vesaratchavest, Direk Limmathurotsakul, Wirongrong Chierakul, Surasakdi Wongratanacheewin, Sasithorn Pukritiyakamee, Nicholas J. White, Nicholas P J Day, Sharon J. Peacock
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24587

Melioidosis is a notoriously protracted illness and is difficult to cure. We hypothesize that the causative organism, Burkholderia pseudomallei, undergoes a process of adaptation involving altered expression of surface determinants which facilitates persistence in vivo and that this is reflected by...