Molecular phylogeny of modern coxsackievirus A16

Molecular phylogeny of modern coxsackievirus A16

A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in...

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Bibliographic Details
Main Authors: D. Perera, M. A. Yusof, Y. Podin, M. H. Ooi, N. T.T. Thao, K. K. Wong, A. Zaki, K. B. Chua, Y. A. Malik, P. V. Tu, N. T.K. Tien, P. Puthavathana, P. C. McMinn, M. J. Cardosa
Other Authors: Universiti Malaysia Sarawak
Format: Article
Published: 2018
Subjects:
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24551
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Institution: Mahidol University
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Summary:A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains. © 2007 Springer-Verlag.

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