Mitochondrial and nuclear p53 localization in cardiomyocytes: Redox modulation by doxorubicin (Adriamycin)?

• Main Authors: Ramaneeya Nithipongvanitch, Wanida Ittarat, Marsha P. Cole, Jitbanjong Tangpong, Daret K. St. Clair, Terry D. Oberley
• 其他作者: University of Wisconsin School of Medicine and Public Health
• 格式: Review
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/24172
• 機構: Mahidol University

Reactive oxygen (ROS) and nitrogen species (RNS) generation have been proposed to be an important mechanism of doxorubicin (Adriamycin; ADR)-induced cardiotoxicity and cardiomyocyte apoptosis, processes that may be mediated by p53 protein. We note that ADR treatment resulted in increased levels of p...