Inhibition of dengue virus replication by mycophenolic acid and ribavirin

• المؤلفون الرئيسيون: Ratree Takhampunya, Sukathida Ubol, Huo Shu Houng, Craig E. Cameron, Radhakrishnan Padmanabhan
• مؤلفون آخرون: Georgetown University School of Medicine
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Immunology and Microbiology
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/23320

Dengue viruses (DEN), mosquito-borne members of the family Flaviviridae, are human pathogens of global significance. The effects of mycophenolic acid (MPA) and ribavirin (RBV) on DEN replication in monkey kidney (LLC-MK2) cells were examined. MPA (IC50=0.4±0.3 μM) and RBV (IC50=50.9±18 μM) inhibited...