COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus
Two new compounds, 3′-(4″-hydroxy-3″,5″- dimethoxyphenyl)-propyl benzoate (1) and 3′-(4″-hydroxyphenyl)- propyl benzoate (3) together with known compounds, 3′-(4″-hydroxy- 3″-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and...
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th-mahidol.231862018-08-20T14:25:27Z COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus Sirivan Athikomkulchai Hunsa Prawat Nopporn Thasana Nijsiri Ruangrungsi Somsak Ruchirawat Chulalongkorn University Chulabhorn Research Institute Mahidol University Chemistry Pharmacology, Toxicology and Pharmaceutics Two new compounds, 3′-(4″-hydroxy-3″,5″- dimethoxyphenyl)-propyl benzoate (1) and 3′-(4″-hydroxyphenyl)- propyl benzoate (3) together with known compounds, 3′-(4″-hydroxy- 3″-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and identified from the branches of Croton hutchinsonianus. Their structures were determined by spectroscopic methods. The three phenylpropyl benzoates (1-3) were found to exhibit antifungal activity against Candida albicans (IC505.36-11.41 μg/ml). Compounds 1-2 (IC502.11-4.95 μg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC501.88 μg/ml) preferentially inhibited the enzyme COX-2. © 2006 Pharmaceutical Society of Japan. 2018-08-20T06:56:53Z 2018-08-20T06:56:53Z 2006-01-01 Article Chemical and Pharmaceutical Bulletin. Vol.54, No.2 (2006), 262-264 10.1248/cpb.54.262 13475223 00092363 2-s2.0-32044458616 https://repository.li.mahidol.ac.th/handle/123456789/23186 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=32044458616&origin=inward |
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Mahidol University Library |
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Asia |
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Chemistry Pharmacology, Toxicology and Pharmaceutics |
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Chemistry Pharmacology, Toxicology and Pharmaceutics Sirivan Athikomkulchai Hunsa Prawat Nopporn Thasana Nijsiri Ruangrungsi Somsak Ruchirawat COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| description |
Two new compounds, 3′-(4″-hydroxy-3″,5″- dimethoxyphenyl)-propyl benzoate (1) and 3′-(4″-hydroxyphenyl)- propyl benzoate (3) together with known compounds, 3′-(4″-hydroxy- 3″-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and identified from the branches of Croton hutchinsonianus. Their structures were determined by spectroscopic methods. The three phenylpropyl benzoates (1-3) were found to exhibit antifungal activity against Candida albicans (IC505.36-11.41 μg/ml). Compounds 1-2 (IC502.11-4.95 μg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC501.88 μg/ml) preferentially inhibited the enzyme COX-2. © 2006 Pharmaceutical Society of Japan. |
| author2 |
Chulalongkorn University |
| author_facet |
Chulalongkorn University Sirivan Athikomkulchai Hunsa Prawat Nopporn Thasana Nijsiri Ruangrungsi Somsak Ruchirawat |
| format |
Article |
| author |
Sirivan Athikomkulchai Hunsa Prawat Nopporn Thasana Nijsiri Ruangrungsi Somsak Ruchirawat |
| author_sort |
Sirivan Athikomkulchai |
| title |
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| title_short |
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| title_full |
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| title_fullStr |
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| title_full_unstemmed |
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus |
| title_sort |
cox-1, cox-2 inhibitors and antifungal agents from croton hutchinsonianus |
| publishDate |
2018 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/23186 |
| _version_ |
1763488747367694336 |