Plasmodium vivax trophozoites insensitive to chloroquine

• Main Authors: Sharrock, Wesley W, Rossarin Suwanarusk, Usa Lek-Uthai, Edstein, Michael D, Varakorn Kosaisavee, Travers, Thomas, Anchalee Jaidee, Kanlaya Sriprawat, Price, Ric N, Nosten, François, Russell, Bruce, อุษา เล็กอุทัย, วรากร โกศัยเสวี
• Format: Article
• Language: English
• Published: 2012
• Subjects: Plasmodium vivax; Malaria; Chloroquine; Polymerization; Trophozoite; Plasmodium falciparum; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2182

Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism i...