p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose

• Main Authors: Chompunoot Sinthepibulyakit, Grimes, Kritopher R., Domann, Frederick E., Fang Fang, Yong Xu, Wanida Ittarat, Daret K. St. Clair, Clair, William St.
• Format: Article
• Language: English
• Published: 2012
• Subjects: 2-deoxy-D-glucose; p53, radiation; Lung cancer; Clonogenic survival
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2115
• Institution: Mahidol University

Metabolic change in cancer cells by preferential production of energy through glycolysis is a well-documented characteristic of cancer. However, whether inhibition of glycolysis will enhance the efficacy of radiation therapy is a matter of debate. In this study which uses lung cancer as the mod...