Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)

• المؤلفون الرئيسيون: Yong XU, Sureerut Porntadavity, Daret K St Clair
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: enzyme induction; oxidative stress; tumour suppressor gene; Open Access article
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/2080

Manganese superoxide dismutase (MnSOD) plays an important role in regulating cellular redox conditions. Expression of MnSOD has been shown to protect against damage by oxidative stress and to suppress the malignant phenotype of human cancer cells. We have previously cloned the human MnSOD (SOD2) gen...