Vicinal dianions of diethyl α-aroylsuccinates: A general synthetic route to α-aroyl- and α-arylidene-γ-butyrolactones

• Main Authors: Manat Pohmakotr, Laddawan Sampaongoen, Arisara Issaree, Patoomratana Tuchinda, Vichai Reutrakul
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/20699

Vicinal dianions derived from diethyl α-aroylsuccinates were found to react with carbonyl compounds β-regioselectively to afford α-aroyl-γ-butyrolactones, which were converted into α-arylidene-γ-butyrolactones by reduction with H2/Pd-C followed by elimination employing methanesulfonyl chloride in py...