Atropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea
The first naturally occurring atropisomeric flavans, myristinins B (2), ] (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| 其他作者: | |
| 格式: | Article |
| 出版: |
2018
|
| 主題: | |
| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/20123 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|
| 總結: | The first naturally occurring atropisomeric flavans, myristinins B (2), ] (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited antifungal activity against Candida albicans with IC50 values ranging from 5.9 to 8.8 μg/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2). |
|---|