Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system

• Main Authors: Suriyan Sukati, Saovaros Svasti, Stifanese, Roberto, Averna, Monica, Nantika Panutdaporn, Tipparat Penglong, Melloni, Edon, Suthat Fucharoen, Katzenmeier, Gerd
• Other Authors: Mahidol University. Institute of Molecular Biosciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Clinical Severity; b-thalassaemia/Hb E; Disease; Associated; Differential; Activities; Calpain-Calpastatin; Proteolytic; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/1805
• Institution: Mahidol University

Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this s...