A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

• المؤلفون الرئيسيون: Simmaly Phongmany, Rattanaphone Phetsouvanh, Siho Sisouphone, Chirapha Darasavath, Pankham Vongphachane, Oudayvone Rattanavong, Mayfong Mayxay, Andrew C. Ramsay, Stuart D. Blacksell, Chanpheng Thammavong, Bounkong Syhavong, Nicholas J. White, Paul N. Newton
• مؤلفون آخرون: Mahosot Hospital
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Immunology and Microbiology; Medicine
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/16582

We conducted a randomized open trial of oral chloramphenicol (50 mg/kg/ day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P < 0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost. © 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.