Asymmetric synthesis of gem-difluoromethylenated dihydroxypyrrolizidines and indolizidines

• Main Authors: Watcharaporn Thaharn, Teerawut Bootwicha, Darunee Soorukram, Chutima Kuhakarn, Samran Prabpai, Palangpon Kongsaeree, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Chemistry
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/13940

An asymmetric synthesis of gem-difluoromethylenated dihydroxypyrrolizidines and indolizidines is described. The fluoride-catalyzed nucleophilic addition of PhSCF 2 SiMe 3 (1) to chiral imides was achieved in satisfactory yields to provide mixtures of syn- and anti-isomers 6-9 with moderate to good...