α,α-Difluoro-α-phenylsulfanyl-α- trimethylsilylmethane as "cF<inf>2</inf>^-" synthetic building block for the preparation of gem-difluoromethylenated cyclopentanols

• Main Authors: Krisana Peewasan, Chutima Kuhakarn, Darunee Soorukram, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13780

A general strategy for the preparation of gem-difluoromethylenated cyclopentanols has been demonstrated; it involves sequential fluoride-catalyzed nucleophilic addition of α,α-difluoro-α-phenylsulfanyl- α-trimethylsilylmethane (PhSCF 2 SiMe 3 ; 1) to homoallyl ketones followed by intramolecular radi...