Understanding resistance mechanisms and expanding the therapeutic utility of PARP inhibitors

• Main Authors: Lim, J.S.J, Tan, D.S.P
• Other Authors: MEDICINE
• Format: Review
• Published: 2020
• Subjects: double stranded DNA; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; niraparib; olaparib; rucaparib; talazoparib; veliparib; acute myeloid leukemia; alopecia; anemia; bone marrow suppression; breast cancer; breast tumor; cancer resistance; cancer survival; DNA end joining repair; DNA strand breakage; drug approval; drug efficacy; drug safety; drug tolerability; esophagus tumor; Ewing sarcoma; fatigue; female genital tract tumor; food and drug administration; gastrointestinal toxicity; gene mutation; germ cell tumor; human; liver dysfunction; lymphocytopenia; lymphoma; neuroendocrine tumor; non small cell lung cancer; nonhuman; outcome assessment; ovary tumor; overall survival; pancreas tumor; progression free survival; prostate tumor; Review; sarcoma; solid malignant neoplasm; somnolence; thrombocytopenia; tumor suppressor gene
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178338

10.3390/cancers9080109