Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks

• المؤلفون الرئيسيون: Vidyasekar P., Shyamsunder P., Arun R., Santhakumar R., Kapadia N.K., Kumar R., Verma R.S.
• مؤلفون آخرون: CANCER SCIENCE INSTITUTE OF SINGAPORE
• التنسيق: مقال
• منشور في: 2019
• الموضوعات: cyclin A2; cyclin dependent kinase 6; microRNA; microRNA 22; transcription factor Sp1; tumor marker; cell cycle protein; oncoprotein; apoptosis; Article; cancer growth; cancer prognosis; CCNA2 gene; CDK6 gene; cell activity; cell cycle regulation; cell population; cell proliferation; cell structure; cell transformation; cell viability; colony formation; colorectal cancer cell line; controlled study; DLD 1 cell line; DNA microarray; down regulation; gene control; gene expression profiling; gene ontology; gene silencing; gene targeting; genome analysis; leukemia cell line; microgravity; MIR17HG gene; MIR21HG gene; MIR22HG gene; MOLT 4 cell line; oncogene; proto oncogene; regulatory mechanism; simulation; SP1 gene; transcription regulation; tumor suppressor gene; upregulation; cell cycle; gene expression regulation; gene regulatory network; genetics; genome-wide association study; human; human genome; metabolism; signal transduction; tumor cell line; weightlessness; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genome, Human; Genome-Wide Association Study; Humans; MicroRNAs; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Signal Transduction; Weightlessness Simulation
• الوصول للمادة أونلاين: https://scholarbank.nus.edu.sg/handle/10635/161491
• المؤسسة: National University of Singapore

10.1371/journal.pone.0135958