O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes

• Main Authors: Kapoor R., Singh S., Tripathi M., Bhatnagar P., Kakkar P., Gupta K.C.
• 其他作者: DUKE-NUS MEDICAL SCHOOL
• 格式: Article
• 出版: 2019
• 主題: berberine; caspase 3; caspase 9; dextran; glucose; nanoparticle; o hexadecyl dextran; phosphatidylserine; protein Bax; protein bcl 2; unclassified drug; DNA; glutathione; nitric oxide; O-hexadecyl-dextran; reactive oxygen metabolite; superoxide dismutase; animal cell; antioxidant activity; apoptosis; article; cell cycle G1 phase; cell membrane depolarization; cell protection; cell stress; cell viability; concentration (parameters); controlled study; drug efficacy; enzyme activation; glucose stress; lipid peroxidation; liver cell; male; mitochondrial membrane potential; nonhuman; oxidative stress; rat; animal; chemistry; dose response; drug effects; metabolism; mitochondrion; particle size; secretion (process); transport at the cellular level; Animals; Apoptosis; Berberine; Biological Transport; Cytoprotection; Dextrans; Dose-Response Relationship, Drug; Glucose; Glutathione; Lipid Peroxidation; Male; Mitochondria; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Superoxide Dismutase
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/161429
• 機構: National University of Singapore

10.1371/journal.pone.0089124