Development of safe and effective RSV vaccine by modified CD4 epitope in g protein core fragment (GcF)

• Main Authors: Cheon I.S., Shim B.-S., Park S.-M., Choi Y., Jang J.E., Jung D.I., Kim J.-O., Chang J., Yun C.-H., Song M.K.
• Other Authors: NUSHS PROJECT
• Format: Article
• Published: 2019
• Subjects: alanine; CD4 antigen; guanine nucleotide binding protein; guanine nucleotide binding protein core fragment; immunoglobulin G; respiratory syncytial virus vaccine; unclassified drug; epitope; G glycoprotein, Respiratory syncytial virus; virus fusion protein; amino acid substitution; animal cell; animal experiment; animal model; article; CD4+ T lymphocyte; controlled study; drug efficacy; drug safety; female; immune response; immunization; immunoglobulin blood level; mouse; nonhuman; Respiratory syncytial pneumovirus; Respiratory syncytial pneumovirus A 2; Respiratory syncytial pneumovirus B; respiratory syncytial virus infection; vaccine production; weight change; weight reduction; animal; chemistry; immunology; safety; Animals; CD4-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Female; Mice; Respiratory Syncytial Virus Vaccines; Safety; Viral Fusion Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161417
• Institution: National University of Singapore

10.1371/journal.pone.0094269