Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase

• المؤلفون الرئيسيون: Rice, Scott A., Kardak, Bharat G., Kelso, Michael J., Yepuri, Nageshwar Rao, Barraud, Nicolas, Mohammadi, Nasim Shah, Kjelleberg, Staffan
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: Biofilms
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99731; http://hdl.handle.net/10220/17528
• المؤسسة: Nanyang Technological University

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-...