Hematologically important mutations : leukocyte adhesion deficiency (first update)

• Main Authors: Holland, Steven M., Belohradsky, Bernd H., Kuijpers, Taco W., Van de Vijver, Edith, Maddalena, Anne, Sanal, Özden, Uzel, Gulbu, Madkaikar, Manisha, de Boer, Martin, Van Leeuwen, Karin, Köker, M. Yavuz, Parvaneh, Nima, Fischer, Alain, Law, S. K. Alex, Klein, Nigel, Tezcan, F. Ilhan, Unal, Ekrem, Patiroglu, Turkan, Schwartz, Klaus, Somech, Raz, Roos, Dirk
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2013
• 在線閱讀: https://hdl.handle.net/10356/99059; http://hdl.handle.net/10220/12687

Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients with LAD suffer from severe bacterial infections and impaired wound healing, accompanied by neutrophilia. In LAD-I, muta...