Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses

• المؤلفون الرئيسيون: Job, Emma R., Deng, Yi-Mo, Barfod, Kenneth K., Tate, Michelle D., Caldwell, Natalie, Reddiex, Scott, Maurer-Stroh, Sebastian, Brooks, Andrew G., Reading, Patrick C.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Immunology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/96902; http://hdl.handle.net/10220/18079

Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the viral hemagglutinin (HA). Glycans on the head of HA promote virus survival by shielding antigenic sites, but highly glycosylated seasonal IAV are ina...