Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

• المؤلفون الرئيسيون: Pestell, Timothy G., Jiao, Xuanmao, Kumar, Mukesh, Peck, Amy R., Prisco, Marco, Deng, Shengqiong, Li, Zhiping, Ertel, Adam, Casimiro, Mathew C., Ju, Xiaoming, Di Rocco, Agnese, Di Sante, Gabriele, Katiyar, Sanjay, Shupp, Alison, Lisanti, Michael P., Jain, Pooja, Wu, Kongming, Rui, Hallgeir, Hooper, Douglas C., Yu, Zuoren, Goldman, Aaron R., Speicher, David W., Laury-Kleintop, Lisa, Pestell, Richard G.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: OPN; Cyclin D1
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87751; http://hdl.handle.net/10220/45547

The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast cancer, associated with poor outcome. Cyclin...