Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria : a randomized, controlled, open-label trial

• المؤلفون الرئيسيون: Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin Wen, Lee, Sue J., Mukaka, Mavuto, Maude, Richard J., Plewes, Katherine, Md. Mahtab Uddin Hassan, Selim Md. Jahangir, Anstey, Nicholas M., Md. Abul Faiz, Tarning, Joel, Oates, John A., Kingston, Hugh W. F., Ghose, Aniruddha, Wattanakul, Thanaporn, Md. Shafiul Haider, Dutta, Prodip K., Md. Akhterul Islam, Shamsul Alam, Zahed, A. S. M., Md. Abdus Sattar, Chowdhury, M. A. Hassan, Herdman, M. Trent, Leopold, Haruhiko, Piera, Kim A, White, Nicholas J., Md. Amir Hossain, Roberts II, L. Jackson, Dondorp, Arjen M., Turner, Gareth D. H., Day, Nicholas P. J.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Science::Medicine; Falciparum Malaria; Acute Kidney Injury
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87102; http://hdl.handle.net/10220/49871

Background: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen’s capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. Methods: This phase 2, open-label, randomized controlled trial conducted at two...