Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement...
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| Main Authors: | , , , |
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| 格式: | Article |
| 語言: | English |
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2017
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| 在線閱讀: | https://hdl.handle.net/10356/83045 http://hdl.handle.net/10220/42376 |
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