Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

• المؤلفون الرئيسيون: Kundu, Subhashri, Biukovic, Goran, Grüber, Gerhard, Dick, Thomas
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: F-ATP synthase; ε subunit
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83045; http://hdl.handle.net/10220/42376

The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement...