The study of dopamine metabolism with LRRK2 variants in Parkinson’s disease

• 主要作者: Kwok, Wei Hao
• 其他作者: Zhao Yi
• 格式: Final Year Project
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• 在線閱讀: http://hdl.handle.net/10356/65657
• 機構: Nanyang Technological University

Background: Parkinson's disease (PD) is a neurodegenerative disease in which symptoms typically appear when a loss of dopaminergic (DA) neurons causes dopamine levels to fall significantly. Leucine rich repeat kinase 2 (LRRK2) gene mutations are the most common genetic cause of PD. Dopamine dec...