Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis

• Main Authors: Kasahara, Kazuyuki, Kerby, Robert L., Aquino-Martinez, Ruben, Evered, Abigail H., Cross, Tzu-Wen L., Everhart, Jessica, Ulland, Tyler K., Kay, Colin D., Bolling, Bradley W., Bäckhed, Fredrik, Rey, Federico E.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Gastrointestinal Microbiome; Quercetin
• Online Access: https://hdl.handle.net/10356/184693
• Institution: Nanyang Technological University

Gut bacterial metabolism of dietary flavonoids results in the production of a variety of phenolic acids, whose contributions to health remain poorly understood. Here, we show that supplementation with the commonly consumed flavonoid quercetin impacted gut microbiome composition and resulted in a sig...