TEX264-mediated selective autophagy directs DNA damage repair

• المؤلفون الرئيسيون: Qi, Yuxia, Suzuki, Sho W.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2025
• الموضوعات: Medicine, Health and Life Sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/183493
• المؤسسة: Nanyang Technological University

DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA...