TEX264-mediated selective autophagy directs DNA damage repair
DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA...
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| اللغة: | English |
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2025
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| الوصول للمادة أونلاين: | https://hdl.handle.net/10356/183493 |
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sg-ntu-dr.10356-1834932025-04-14T15:33:23Z TEX264-mediated selective autophagy directs DNA damage repair Qi, Yuxia Suzuki, Sho W. School of Biological Sciences Medicine, Health and Life Sciences DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy. Nanyang Technological University National Research Foundation (NRF) Submitted/Accepted version This work was supported by a start-up grant from the School of Biological Sciences, Nanyang Technological University, and the National Research Foundation (NRF) Singapore through a NRF fellowship awarded to S.W.S. (NRF-NRFF15-2023-0006). 2025-04-11T02:05:41Z 2025-04-11T02:05:41Z 2025 Journal Article Qi, Y. & Suzuki, S. W. (2025). TEX264-mediated selective autophagy directs DNA damage repair. Trends in Biochemical Sciences, 50(1), 4-5. https://dx.doi.org/10.1016/j.tibs.2024.10.012 1362-4326 https://hdl.handle.net/10356/183493 10.1016/j.tibs.2024.10.012 39550277 2-s2.0-85209102991 1 50 4 5 en NRF-NRFF15-2023-0006 NTU-SUG Trends in Biochemical Sciences © 2024 Elsevier Ltd. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1016/j.tibs.2024.10.012. application/pdf |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NTU Library |
| collection |
DR-NTU |
| language |
English |
| topic |
Medicine, Health and Life Sciences |
| spellingShingle |
Medicine, Health and Life Sciences Qi, Yuxia Suzuki, Sho W. TEX264-mediated selective autophagy directs DNA damage repair |
| description |
DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Qi, Yuxia Suzuki, Sho W. |
| format |
Article |
| author |
Qi, Yuxia Suzuki, Sho W. |
| author_sort |
Qi, Yuxia |
| title |
TEX264-mediated selective autophagy directs DNA damage repair |
| title_short |
TEX264-mediated selective autophagy directs DNA damage repair |
| title_full |
TEX264-mediated selective autophagy directs DNA damage repair |
| title_fullStr |
TEX264-mediated selective autophagy directs DNA damage repair |
| title_full_unstemmed |
TEX264-mediated selective autophagy directs DNA damage repair |
| title_sort |
tex264-mediated selective autophagy directs dna damage repair |
| publishDate |
2025 |
| url |
https://hdl.handle.net/10356/183493 |
| _version_ |
1831146445027147776 |