Brain macrophages in Alzheimer's disease: from ontogeny to function

• 主要作者: Wu, Xiaoting
• 其他作者: Ruedl Christiane
• 格式: Thesis-Doctor of Philosophy
• 語言: English
• 出版: Nanyang Technological University 2024
• 主題: Medicine, Health and Life Sciences; Alzheimer's disease; Microglia; Border-associated macrophages; Ontogeny; Lipid droplet
• 在線閱讀: https://hdl.handle.net/10356/176738
• 機構: Nanyang Technological University

In the Alzheimer’s disease (AD) brain, microglia and border-associated macrophages (BAMs) undergo dynamic identity changes and display distinct activation and functional (or dysfunctional) states, which remains to be fully elucidated. Using an APP-KI AD mouse model, we demonstrated that microglia an...