Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein

• المؤلفون الرئيسيون: Loh, Jia Tong, Teo, Joey Kay Hui, Lam, Kong-Peng
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Neutrophils; Calprotectin
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171049
• المؤسسة: Nanyang Technological University

Increased neutrophils and elevated level of circulating calprotectin are hallmarks of severe COVID-19 and they contribute to the dysregulated immune responses and cytokine storm in susceptible patients. However, the precise mechanism controlling calprotectin production during SARS-CoV-2 infection re...