Obstacles for T-lymphocytes in the tumour microenvironment: therapeutic challenges, advances and opportunities beyond immune checkpoint

• المؤلفون الرئيسيون: Verma, Navin Kumar, Wong. Brandon Han Siang, Poh, Zhi Sheng, Udayakumar, Aiswarya, Verma, Ritu, Goh, Ryan Kwang Jin, Duggan, Shane P., Shelat, Vishalkumar Girishchandra, Chandy, Kanianthara George, Grigoropoulos, Nicholas Francis
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Immunotherapy; Ionic Checkpoint
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/168685

The tumour microenvironment (TME) imposes a major obstacle to infiltrating T-lymphocytes and suppresses their function. Several immune checkpoint proteins that interfere with ligand/receptor interactions and impede T-cell anti-tumour responses have been identified. Immunotherapies that block immune...