Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications

• المؤلفون الرئيسيون: Mao, Xiaoyuan, Wang, Xuan, Jin, Mingzhu, Li, Qin, Jia, Jining, Li, Menghuan, Zhou, Honghao, Liu, Zhaoqian, Jin, Weilin, Zhao, Yanli, Luo, Zhong
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Drug Delivery; Ferroptosis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/164869
• المؤسسة: Nanyang Technological University

Recent insights collectively suggest the important roles of lysyl oxidase (LysOX) in the pathological processes of several acute and chronic neurological diseases, but the molecular regulatory mechanisms remain elusive. Herein, we explore the regulatory role of LysOX in the seizure-induced ferroptot...