Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

• Main Authors: Kinnebrew, Maia, Luchetti, Giovanni, Sircar, Ria, Frigui, Sara, Viti, Lucrezia Vittoria, Naito, Tomoki, Beckert, Francis, Saheki, Yasunori, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Medicine; Cell Membrane; Cholesterol
• 在線閱讀: https://hdl.handle.net/10356/160768

A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al., 2019) that PTCH1 inhibits Smoothened by depl...