Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al., 2019) that PTCH1 inhibits Smoothened by depl...

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書目詳細資料
Main Authors:	Kinnebrew, Maia, Luchetti, Giovanni, Sircar, Ria, Frigui, Sara, Viti, Lucrezia Vittoria, Naito, Tomoki, Beckert, Francis, Saheki, Yasunori, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
其他作者:	Lee Kong Chian School of Medicine (LKCMedicine)
格式:	Article
語言:	English
出版:	2022
主題:	Science::Medicine Cell Membrane Cholesterol
在線閱讀:	https://hdl.handle.net/10356/160768
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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