Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

• المؤلفون الرئيسيون: Kinnebrew, Maia, Luchetti, Giovanni, Sircar, Ria, Frigui, Sara, Viti, Lucrezia Vittoria, Naito, Tomoki, Beckert, Francis, Saheki, Yasunori, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Medicine; Cell Membrane; Cholesterol
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/160768

A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al., 2019) that PTCH1 inhibits Smoothened by depl...