Role of lipid droplets and FITM2 in beta-cell physiology and pathophysiology

• المؤلف الرئيسي: Ho, Calvin Qing Wei
• مؤلفون آخرون: Yusuf Ali
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2022
• الموضوعات: Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/158047
• المؤسسة: Nanyang Technological University

Hyperlipidemia is a known driving factor of T2DM, with saturated fatty acids (SFAs) pinpointed as the causation of β cell failure. Hence, intracellular handling of these SFAs, in β cells, was thought to be vital in preventing the loss of its function. The biogenesis of lipid droplets (LDs) forms an...