Discovery of hyperstable noncanonical plant-derived epidermal growth factor receptor agonist and analogs

• Main Authors: Loo, Shining, Kam, Antony, Li, Binbin, Feng, Nan, Wang, Xiaoliang, Tam, James P.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Biological sciences::Biochemistry; Science::Medicine; Amino Acid Motifs; Epidermal Growth Factor Receptor
• 在線閱讀: https://hdl.handle.net/10356/156118
• 機構: Nanyang Technological University

Here, we report the discovery of the first plant- derived and noncanonical epidermal growth factor receptor (EGFR) agonist, the 36-residue bleogen pB1 from Pereskia bleo of the Cactaceae family. We show that bleogen pB1 is a low-affinity EGFR agonist using a suite of chemical, biochemical, cellu...