Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes
Objective:b-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. We previouslyshowed that increased miR-7 levels triggerb-cell dedifferentiation and diabetes. We usedb-cell-specific miR-7 overexpressing mice (Tg7) to testthe hypothesis t...
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| Main Authors: | , , , , , , , , , , , , , |
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| 其他作者: | |
| 格式: | Article |
| 語言: | English |
| 出版: |
2022
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| 主題: | |
| 在線閱讀: | https://hdl.handle.net/10356/153886 |
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