A chemically defined feeder-free system for the establishment and maintenance of the human naive pluripotent state

• المؤلفون الرئيسيون: Szczerbinska, Iwona, Gonzales, Kevin Andrew Uy, Cukuroglu, Engin, Muhammad Nadzim Bin Ramli, Lee, Bertha Pei Ge, Tan, Cheng Peow, Wong, Cheng Kit, Rancati, Giulia Irene, Liang, Hongqing, Göke, Jonathan, Ng, Huck-Hui, Chan, Yun-Shen
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Feeder-free System; Naive Pluripotent State
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/143817

The distinct states of pluripotency in the pre- and post-implantation embryo can be captured in vitro as naive and primed pluripotent stem cell cultures, respectively. The study and application of the naive state remains hampered, particularly in humans, partially due to current culture protocols re...