Carbene-catalyzed enantioselective addition of benzylic carbon to unsaturated acyl azolium for rapid synthesis of pyrrolo[3,2- c]quinolines

• المؤلفون الرئيسيون: Wang, Jilan, Li, Yongjia, Sun, Jun, Wang, Hong, Jin, Zhichao, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Chemistry::Organic chemistry; Carbene Organocatalysis; Asymmetric Synthesis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/138266
• المؤسسة: Nanyang Technological University

A carbene-catalyzed enantioselective addition of benzylic carbon to α,β-unsaturated acyl azolium intermediate generated via N-heterocyclic carbene catalysis is disclosed. This addition is followed by a stereoselective Mannich reaction and a chemo-selective lactam formation cascade to afford pyrrolo[...