The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

• Main Authors: Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter
• 其他作者: Leng, Fenfei
• 格式: Article
• 語言: English
• 出版: 2019
• 主題: HT1080 Cells; DNA Replication; DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/105922; http://hdl.handle.net/10220/48858

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...