The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

• المؤلفون الرئيسيون: Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter
• مؤلفون آخرون: Leng, Fenfei
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: HT1080 Cells; DNA Replication; DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/105922; http://hdl.handle.net/10220/48858
• المؤسسة: Nanyang Technological University

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...