ANALISIS SITOGENETIK KARIOLISIS EPITEL MUKOSA BUKAL PADA PEKERJA DRY CLEANING DI YOGYAKARTA
Dry cleaning is washing procedure using chemical solvent other than water. The most frequent chemical solvent used in dry cleaning is perchloroethylene which is suspected to have toxic property and possibility to poison human body by means of oral ingestion and inhalation. The degree of toxicity of...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/130028/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70439 |
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| Summary: | Dry cleaning is washing procedure using chemical solvent other than water.
The most frequent chemical solvent used in dry cleaning is perchloroethylene
which is suspected to have toxic property and possibility to poison human body by
means of oral ingestion and inhalation. The degree of toxicity of material can be
measured by evaluating cellular necrosis in affected tissue. As one of the stages of
cellular necrosis, karyolysis is mostly chosen to measure material toxicity since
the frequency of karyolysis can describe degree of necrosis. The aim of this study
was to evaluate karyolysis frequency in buccal mucosal epithelial cells of dry
cleaning workers in Yogyakarta.
An exfoliative cytology techniques of buccal mucosal epithel was used to
assess karyolysis frequency. Twelve drycleaning workers who have direct and
daily exposure to perchloroethylene were chosen for subjects of this study.
Twelvestudents of Faculty of Dentistry Universitas Gadjah Mada who didn�t have
the risk of perchloroethylene exposure were chosen for control group. All subjects
swabbedin left side of buccal mucosal epithel with cytobrush. Swabbed specimens
were dyed usingFeulgen-Rossenbeck modification technique and evaluated
microscopically per 1000 cells.
Results of this study showed that karyolysis frequency of buccal mucosal
epithelial cells in perchloroethylene exposed group was significantly different
compared to control group. It is concluded that there were relationship between
perchloroethyleneexposurewithincreasing of karyolysis frequency in buccal
mucosal epithelial cells and occur 7 years after exposure significantly. |
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